|
Symbol Name ID |
Pparg
peroxisome proliferator activated receptor gamma MGI:97747 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Lymphadenopathy |
Splenomegaly |
Hepatosplenomegaly |
Helicobacter pylori infection |
Peritoneal abscess |
Pancreatitis |
Autoimmunity |
| Disease(s) Associated with PPARG | |||||||
| familial partial lipodystrophy type 3 | |||||||
| pancreatic cancer | |||||||
| pre-eclampsia |
| Mouse Phenotypes | immune system phenotype |
abnormal osteoclast differentiation |
increased B cell proliferation |
impaired macrophage phagocytosis |
enlarged spleen |
abnormal T-helper 17 cell differentiation |
decreased osteoclast cell number |
abnormal osteoclast morphology |
abnormal peritoneal macrophage morphology |
abnormal spleen morphology |
abnormal splenocyte morphology |
increased splenocyte number |
abnormal B cell physiology |
increased IgG level |
increased IgM level |
abnormal macrophage physiology |
abnormal macrophage activation involved in immune response |
leukostasis |
abnormal bone marrow development |
abnormal humoral immune response |
increased interferon-gamma secretion |
increased interleukin-2 secretion |
increased susceptibility to experimental autoimmune encephalomyelitis |
increased susceptibility to induced arthritis |
increased autoantibody level |
increased anti-nuclear antigen antibody level |
increased anti-double stranded DNA antibody level |
increased anti-single stranded DNA antibody level |
glomerulonephritis |
skin inflammation |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||
| Ppargtm1Tka/Pparg+ | * | ||||||||||||||||||||||||||||||
| Ppargtm1Wwah/Pparg+ | * | ||||||||||||||||||||||||||||||
| Ppargtm1.1Gonz/Ppargtm1.1Gonz Tg(Mx1-cre)1Cgn/? (conditional) |
|||||||||||||||||||||||||||||||
| Ppargtm1.1Gonz/Ppargtm1.1Gonz Lyz2tm1(cre)Ifo/Lyz2+ (conditional) |
|||||||||||||||||||||||||||||||
| Ppargtm2Rev/Ppargtm2Rev Tg(Tek-cre)1Ywa/? (conditional) |
|||||||||||||||||||||||||||||||
| Ppargtm2Rev/Ppargtm2Rev Tg(Krt1-15-cre/PGR*)22Cot/? (conditional) |
|||||||||||||||||||||||||||||||
| Ppargtm2Rev/Ppargtm2Rev Tg(Cd4-cre)1Cwi/? (conditional) |
|||||||||||||||||||||||||||||||
| Ppargtm2Rev/Ppargtm2Rev Tg(Tek-cre)12Flv/? (conditional) |
|||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/23/2024 MGI 6.23 |
|
|
|
||
Analysis Tools